Effect of human recombinant granulocyte colony-stimulating factor on hematopoietic injury in mice induced by 5-fluorouracil.

نویسندگان

  • M Shimamura
  • Y Kobayashi
  • A Yuo
  • A Urabe
  • T Okabe
  • Y Komatsu
  • S Itoh
  • F Takaku
چکیده

Intravenous (IV) administration of 5-fluorouracil (5-FU) caused severe hematopoietic injury in mice. Daily administration of purified human recombinant granulocyte colony-stimulating factor (rG-CSF) accelerated recovery from neutropenia in these injured mice. Granulocyte-macrophage progenitors (CFU-GM) in spleen were markedly increased by rG-CSF, while rG-CSF was less effective on the regeneration of CFU-GM in femoral marrow. The accelerated recovery from neutropenia in the mice might be mainly due to the stimulation of granulopoiesis in spleen by rG-CSF.

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عنوان ژورنال:
  • Blood

دوره 69 1  شماره 

صفحات  -

تاریخ انتشار 1987